ارزیابی اثر آنتی اکسیدانی و کاهندگی برخی فاکتورهای انعقادی عصاره هیدروالکلی موسیر در خرگوش های هایپرکلسترولمیک

Background and purpose: Hypercholesterolemia and the activity of haemostatic factors may trigger cardiovascular diseases. Allium hirtifolium Boiss (Persian shallot) has been shown to have cardioprotective effects. This study evaluated the effects of A. hirtifoliumon on factor VII and serum fibrinogen levels in hypercholesterolemic rabbits. Also, the antioxidant capacity of A. hirtifolium was measured. Materials and methods: In an experimental study, 24 NewZealand male rabbits were randomly assigned into three groups of eight. The groups' diet which was followed for 60 days included normal diet, hypercholestrol diet (1%) or hypercholestrol diet (1%) + A. hirtifolium. The blood fibrinogen and factor VII were measured pre and post study in all groups. The A. hirtifolium antioxidant capacity was measured using beta-carotene linoleate. Results: The study showed that serum fibrinogen level and factor VII increased significantly in hypercholesterolemic group (329.22 ± 26.7 and 277.7 ± 17.1 mg/dl) compared to normal diet group (287.25 ± 13.7 and 230.0 ± 18.2 mg/dl), respectively (P<0.05). The amount of serum fibrinogen and factor VII decreased in hypercholesterol+A. hirtifolium group (180.0 ± 23.9 and 237.0 ± 53.3 mg/dl) compared to hypercholesterol diet group (P<0.05). The antioxidant capacity of A. hirtifolium extract was 52.1 ± 3.3% in 0.2 g/L. The plasma antioxidant capacity in the group fed with hypercholesterol + A. hirtifolium was 943.907 ± 249.51 µM which was higher compared to that of the normal diet group (629.675 ± 130.73 µM). Conclusion: A. hirtifolium decreases serum fibrinogen level and factor VII, therefore, it might be helpful in reducing risk factors of cardiovascular diseases. These influences are of great importance in patients with haemostatic disorders.